Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) Y140F mutant complexed with itraconazole

Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) Y140F mutant complexed with itraconazole Descriptor: 2-[(2R)-butan-2-yl]-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-2,4-dihydro-3H-1,2,4-triazol-3-one, Lanosterol 14-alpha demethylase, PROTOPORPHYRIN IX CONTAINING FE Authors: Sagatova, A, Keniya, M.V, Wilson, R.K, Tyndall, J.D.A, Monk, B.C. Deposit date: 2015-04-20 Release date: 2016-03-30 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.02 Å) Cite: Triazole resistance mediated by mutations of a conserved active site tyrosine in fungal lanosterol 14 alpha-demethylase. Sci Rep, 6, 2016

酿酒酵母（Saccharomyces cerevisiae）CYP51（羊毛甾醇14-α-去甲基酶，Lanosterol 14-alpha demethylase）Y140F突变体与伊曲康唑（itraconazole）的复合物。描述项：2-[(2R)-丁-2-基]-4-{4-[4-(4-{[(2R,4S)-2-(2,4-二氯苯基)-2-(1H-1,2,4-三唑-1-基甲基)-1,3-二氧戊环-4-基]甲氧基}苯基)哌嗪-1-基]苯基}-2,4-二氢-3H-1,2,4-三唑-3-酮、羊毛甾醇14-α-去甲基酶（Lanosterol 14-alpha demethylase）、含铁原卟啉IX（PROTOPORPHYRIN IX CONTAINING FE）。作者：Sagatova A、Keniya M.V、Wilson R.K、Tyndall J.D.A、Monk B.C。提交日期：2015-04-20；发布日期：2016-03-30；最后修改日期：2024-03-13。实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率2.02 Å）。引用文献：《真菌羊毛甾醇14α-去甲基酶保守活性位点酪氨酸突变介导的三唑耐药性》，刊载于《科学报告》（Sci Rep）第6卷，2016年。