Fitting parameters for the 10 mM nicotine CT response in the presence of increasing concentrations of DHβE and Mec using Eq 2.

i = Mec or DHβE
ri = response at Mec or DHβE concentration ci
ai = maximum part of the response sensitive to inhibitor i, which occurs when ci = 0
ki = the dissociation constant between inhibitor i and an inhibitor-sensitive nAChR
ni = a constant >1 consistent with the positively cooperative nature of the inhibitor-nAChR interaction
rit = rt + ri0, where rt the response due to T2Rs and ri0 is the part of the response insensitive to Mec when Mec is the inhibitor applied with nicotine or the part of the response insensitive to DHβE when DHβE is the inhibitor applied with nicotine
*p = 0.0216 (N = 3)
Fitting parameters for the 10 mM nicotine CT response in the presence of increasing concentrations of DHβE and Mec using Eq 2.