Results of epigenome wide association of hearing PC1 for discovery and replication samples and their meta-analysis.

The ten most highly associated differentially methylated regions in the discovery EWAS (27 k) are shown. Probes are characterised by the nearest gene, the association effect (beta), standard error of the effect (se) and significance of model fit (p-value). Significance of model fit excluding age as a model parameter (p-value (no age)) is reported for both the discovery (27 k) and replication (450 k) sample. The ten most highly associated probes were taken forward for replication (450 k) with effect (beta) standard error of the effect and significance of model fit (p-value) listed. Results of the meta-analysis are presented as direction of effect (dir, discovery and replication direction shown), combined effect (beta), standard error of the combined effect (se) and significance of the combined association (p-value). Association of DNA methylation and hearing PC1 was replicated for probes cg01161216 and cg18877514 (highlighted in bold).Results of epigenome wide association of hearing PC1 for discovery and replication samples and their meta-analysis.