RNA Sequencing of peripheral blood mononuclear cells (PBMCs) isolated from epilepsy patients treated with vagus nerve stimulation and not treated with vagus nerve stimulation.. RNA Sequencing of peripheral blood mononuclear cells (PBMCs) isolated from epilepsy patients treated with vagus nerve stimulation and not treated with vagus nerve stimulation.

Purpose: To decipher the mechanisms responsible for the protective function of vagus nerve stimulation. Methods: Blood was collected from Control and Treated patients followed by isolation of PBMC'S. Total RNA was extracted and RNA sequencing was done following standard protocols Results: Detailed analysis of the transcriptomic data show that anti-inflammatory responses were upregulated in the treated samples. Conclusions: This study showed the protective role of vagus nerve stimulation in epilepsy patients. Overall design: Human PBMC's RNA seq of 4 control and treated 4 patients, using Illumina platform