首页/数据集/SUZ12 and NF1 loss cooperate to enhance Ras transcriptional output and sensitize cancers to epigenetic therapies

SUZ12 and NF1 loss cooperate to enhance Ras transcriptional output and sensitize cancers to epigenetic therapies

ChEBI2014-07-01 更新2026-07-21 收录

RAS通路调控

癌症表观遗传治疗

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-52777 数据链接链接失效反馈

官方服务：

资源简介：

SUZ12 and NF1 loss cooperate to enhance Ras transcriptional output and sensitize cancers to epigenetic therapies

应用场景：

创建时间：

2014-07-01

癌症表观遗传治疗

重复元件转录调控

Abstract: Epithelial ovarian carcinomas (OC) are particularly deadly due to intratumoral heterogeneity, resistance to standard-of-care therapies, and poor response to alternative treatments such as im

NIAID Data Ecosystem70

SMARCA4 Phosphorilation inhibition

癌症表观遗传治疗

激酶抑制剂开发

Cyclin-Dependent Kinase 9 (CDK9) as part of the PTEFb complex promotes transcriptional elongation and high-level gene expression. We now report that, paradoxically, CDK9 is also essential for maintain

NIAID Data Ecosystem30

Catalytic-independent functions of INTAC confer sensitivity to BET inhibition [RNA-seq]

癌症表观遗传治疗

药物耐药机制

Chromatin and transcription regulators are critical to defining cell identity through shaping epigenetic and transcriptional landscapes, with their misregulation being closely linked to oncogenesis. P

NIAID Data Ecosystem20

ERF deletion rescues RAS deficiency in mouse embryonic stem cells [ChIP-seq]. Mus musculus

RAS通路调控

干细胞分化

RAS proteins are key regulators of growth factor signaling. Here we show that deletion of all RAS genes in mouse embryonic stem cells (mES) leads to an overall reduction in protein translation, limits

NIAID Data Ecosystem40

Membrane-targeting potentiates guanine nucleotide exchange factor CDC25 and SOS1 activation of Ras transforming activity.

RAS通路调控

癌症转化机制研究

Growth factor-triggered activation of Ras proteins is believed to be mediated by guanine nucleotide exchange factors (CDC25/GRF and SOS1/2) that promote formation of the active Ras GTP-bound state. Al

PubMed Central1994-08-30 更新20

SUZ12 and NF1 loss cooperate to enhance Ras transcriptional output and sensitize cancers to epigenetic therapies

资源简介：

相关数据集