Research data supporting: "Understanding the genetic complexity of puberty timing across the allele frequency spectrum"

This dataset is made up of GWAS meta-analysis for age at menarche (AAM), in up to 799,845 women. All studies provided GWAS data imputed to at least 1000 Genomes reference panel density, yielding a total of ~12.7 million genetic variants in the final meta-analysis. Variants were meta-analysed using a fixed-effects inverse-variance-weighted model in METAL and filtered to include minor allele frequency (MAF) >= 0.1%.

Summary statistics made available for download are from an analysis excluding 23andMe (ancestry combined up to n=723,014 and European-only up to n=556,124) and following all the filtering steps as outlined above.

Datasets available for download:
1) Ancestry combined GWAS summary statistics
Menarche2024_AncestryCombined_RELEASE_EXC23andMe.txt.gz
2) European-only GWAS summary statistics
Menarche2024_EuropeanOnly_RELEASE_EXC23andMe.txt.gz
Both tab-delimited files, with one row per SNP including the same columns as the above.

For further information please check the supplied readme file or the associated publication.

本数据集由关于初潮年龄（AAM）的GWAS（全基因组关联研究）荟萃分析构成，涉及直至799,845名女性的研究。所有研究均提供了至少基于1000 Genomes参考面板密度的GWAS数据，最终荟萃分析中产生了约1,270万遗传变异。变异体采用固定效应逆方差加权模型在METAL中进行荟萃分析，并经过筛选，以包括等位基因频率（MAF）不低于0.1%的变异体。

可供下载的汇总统计信息来自排除23andMe（祖先混合至n=723,014和仅欧洲血统至n=556,124）的分析，并遵循上述所述的所有筛选步骤。

可供下载的数据集包括：
1) 祖先混合GWAS汇总统计信息
Menarche2024_AncestryCombined_RELEASE_EXC23andMe.txt.gz
2) 仅欧洲血统GWAS汇总统计信息
Menarche2024_EuropeanOnly_RELEASE_EXC23andMe.txt.gz
均为制表符分隔的文件，每行包含一个SNP（单核苷酸多态性），包括与上述相同的列。

如需进一步信息，请查阅所提供的readme文件或相关出版物。