Additional file 12 of Gene networks and transcriptional regulators associated with liver cancer development and progression

Additional file 12. Master regulator molecules of genes upregulated in GE2-hepatocellular carcinoma (HCC). Significantly up regulated genes in GE2-HCC (n=13) versus NT (n=17) samples with mean fold change (FC) ≥ 2 and false discovery rate (FDR) ≤ 0.05 were identified (Additional file 5) and used as an input gene list for bioinformatics analyses. Master regulator molecules in the signal transduction pathways, at a distance of up to 10 steps upstream of the dysregulated genes, were identified using the curated database of pathways and protein interactions TRANSPATH®.