Maternal Asthma During Pregnancy Imprints Fetal Lung Group 2 Innate Lymphoid Cells and Enhances Their Function in Adulthood [scATAC-Seq]

We investigated the effects on the lungs during fetal in the offspring of asthmatic mothers. ILC2 in the fetal and adult lungs of offspring of asthmatic mothers showed overlapping chromatin accessible altered regions Overall design: Fetal lungs were harvested on gestation day 18 from OVA- or PBS- treated mothers and adult lungs were 8 weeks old offspring of OVA- or PBS- treated mothers. (E18-OVA, n = 8; E18-PBS, n = 9; Adult-OVA-PBS, n = 6; Adult-OVA-PBS, n = 7).