Physical activity is associated with exercise capacity among patients undergoing chemotherapy: a pilot randomized controlled trial

Exercise intolerance is common among cancer patients undergoing active treatments.\ We conducted a pilot study in patients receiving potentially cardiotoxic therapies to investigate the\ impact of participation in a 6-month physical activity intervention (PAI) versus a healthy lifestyle\ education control intervention (HLI) on accelerometer-derived measures of PA (steps/day or minutes\ of moderate to vigorous PA [MVPA]/week) and whether these measures were associated with\ submaximal exercise capacity (6-minute walk distance [6MWD]). Participants with breast\ cancer or lymphoma (n=33) were randomized (2:1) into PAI or HLI groups. Exercise training was\ patient-centered, tailored to treatment and functional status. Objective assessments of PA (steps/day,\ MVPA/week), and submaximal exercise capacity (6MWD) were completed at baseline, 3-, and 6-\ months. Separate linear mixed-effects regression models examined changes in 6MWD, controlling\ for baseline values, a treatment group x time int..., , , # Physical activity is associated with exercise capacity among patients undergoing chemotherapy: a pilot randomized controlled trial Dataset DOI: [10.5061/dryad.w6m905qzp](10.5061/dryad.w6m905qzp) ## Description of the data and file structure Participants who were between 18 to 85 years of age, diagnosed with stage I-IV Hodgkin’s or non-Hodgkin’s lymphoma, or stage I–III breast cancer, were recruited to a 6-month exercise intervention study. Data were collected at baseline, 3, and 6 months. ### Files and variables #### File: PLOS_data_8.13.25.csv **Description:** ##### Variables * pid: participant identification * age: age in years * race: race (White vs. non White) * sex: Female or Male * visit: baseline, 3 months, and 6 months * arm: PAI, physical activity intervention. HLI, Healthy Living Intervention * smwd: Six-minute walk distance * daily_steps: Steps per day as measured with accelerometry, * weekly_mvpa: Moderate to vigorous physical activity in minutes per week. * max..., Direct identifiers (e.g., names, addresses, phone numbers, email addresses, social security numbers) have been removed from the uploaded data. Indirect Identifiers and potentially identifying information like demographic data (age, gender, race, ethnicity), geographic information, dates, and other variables that could be combined to re-identify individuals have been suppressed or are not part of the analytic dataset.