Global analysis of the zinc homeostasis network in Pseudomonas aeruginosa (DOI: 10.3389/fmicb.2021.739988)

In this study we followed up the dynamics of all genes involved in zinc homeostasis in Pseudomonas aeruginosa from starvation to excess, as it happens during infection. The results showed a hierarchical induction of the export systems and a global repression of import mechanisms In this study, three cultures of wild type Pseudomonas aeruginosa, followed up for 60 min after zinc induction, were used to acquire mRNA counts of 25 target genes and 4 reference genes.