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The effect of CDK6 expression on DNA methylation and DNMT3B regulation

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https://www.ncbi.nlm.nih.gov/sra/SRP248610
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资源简介:
We performed methylation analyses in BCR-ABL+ cells either expressing or lacking CDK6 using the next-generation sequencing approach RRBS and identified DNA methylation changes towards both hyper- and hypomethylation. CDK6 mediated methylation changes are largely reverted by CDK6 re-expression in this experimental system. Overall design: 3 BCR-ABL+/CDK6wt cell lines, 3 BCR-ABL+/CDK6-/- cell lines, 3 BCR-ABL+/CDK6-/-+Cdk6 cell lines.
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2023-09-26
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