Transcriptome change mediated by tumor-intrinsic PRC2 inactivation in transplant murine breast cancer AT3 tumor model in C57BL/6J mice
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE179703
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We used CRISPR/Cas9-mediated knockout of PRC2 core components, Eed and generated PRC2-isogenic murine mammary tumor model (AT3, sgCon vs. sgEed ) amenable for syngeneic transplant in C57BL/6J mice. Transcriptome analysis of the explanted PRC2-wt (sgCon) and PRC2-loss (sgEed) AT3 tumors by RNA-seq demonstrated that PRC2 loss led to the upregulation of various developmental pathways, and the downregulation of both innate and adaptive immune response pathways. mRNA profiles of AT3 sgCon and sgEed tumors after mammary fat pad grafting in C57BL/6J mice
创建时间：
2022-08-17
