Structure of GntC, a PLP-dependent enzyme catalyzing L-enduracididine biosynthesis from (S)-4-hydroxy-L-arginine, with the substrate bound

Protein Data Bank Japan2023-11-15 更新2026-04-19 收录

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Structure of GntC, a PLP-dependent enzyme catalyzing L-enduracididine biosynthesis from (S)-4-hydroxy-L-arginine, with the substrate bound Descriptor: (2S,4S)-5-carbamimidamido-4-hydroxy-2-[(E)-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)amino]pentanoic acid (non-preferred name), Aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme, MAGNESIUM ION Authors: Chen, P.Y.-T, Moore, B.S. Deposit date: 2022-12-10 Release date: 2023-04-12 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.04 Å) Cite: Mechanistic and Structural Insights into a Divergent PLP-Dependent l-Enduracididine Cyclase from a Toxic Cyanobacterium. Acs Catalysis, 13, 2023

结合底物状态的GntC晶体结构：该酶为吡哆醛磷酸（Pyridoxal Phosphate, PLP）依赖型酶，催化以(S)-4-羟基-L-精氨酸为底物合成L-内乌拉吉啶底物描述：(2S,4S)-5-胍基-4-羟基-2-[(E)-({3-羟基-2-甲基-5-[(膦酰氧基)甲基]吡啶-4-基}亚甲基)氨基]戊酸（非优选名称）、具有I/II类氨基转移酶折叠结构的吡哆醛磷酸依赖型酶、镁离子作者：Chen, P.Y.-T、Moore, B.S. 提交日期：2022-12-10 发布日期：2023-04-12 最后修改日期：2023-11-15 实验方法：X射线衍射（分辨率2.04埃）引用文献：《产毒蓝细菌来源的分支型PLP依赖型L-内乌拉吉啶环化酶的机制与结构解析》，ACS催化，第13卷，2023年

创建时间：

2022-12-10