Crystal structure of spleen tyrosine kinase complexed with [6-((S)-2-Methyl-pyrrolidin-1-yl)-pyridin-2-yl]-(6-phenyl-imidazo[1,2-b]pyridazin-8-yl)-amine

Crystal structure of spleen tyrosine kinase complexed with [6-((S)-2-Methyl-pyrrolidin-1-yl)-pyridin-2-yl]-(6-phenyl-imidazo[1,2-b]pyridazin-8-yl)-amine Descriptor: N-{6-[(2S)-2-methylpyrrolidin-1-yl]pyridin-2-yl}-6-phenylimidazo[1,2-b]pyridazin-8-amine, Tyrosine-protein kinase SYK Authors: Kuglstatter, A, Slade, M. Deposit date: 2012-07-06 Release date: 2013-01-30 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Rational design of highly selective spleen tyrosine kinase inhibitors. J.Med.Chem., 55, 2012

与N-{6-[(2S)-2-甲基吡咯烷-1-基]吡啶-2-基}-6-苯基咪唑并[1,2-b]吡嗪-8-胺结合的脾酪氨酸激酶（spleen tyrosine kinase）的晶体结构。描述符：N-{6-[(2S)-2-甲基吡咯烷-1-基]吡啶-2-基}-6-苯基咪唑并[1,2-b]吡嗪-8-胺，酪氨酸蛋白激酶SYK。作者：Kuglstatter, A、Slade, M.。沉积日期：2012-07-06。发布日期：2013-01-30。最后修改：2023-09-13。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.85埃（Å）。引用文献：《高选择性脾酪氨酸激酶抑制剂的理性设计》，《J.Med.Chem.》，第55卷，2012年。