Sub-chronic administration of AM6545 enhances cognitive performance and induces hippocampal synaptic plasticity changes in naïve mice

Using RNA sequencing, we perform gene expression profile of three female mice treated with vehicle and four female mice sub-chronically treated with AM6545 at a dose of 1 mg/kg. To evaluate hippocampal modifications promoted by peripheral CB1R modulation, we analyze at transcript level hippocampal synaptoneurosomes fractions. Overall design: mRNA profiles of hippocampal synaptoneurosomes from wild-type female mice after sub-chronic AM6545 or vehicle administration.