Elevated myocardial SORBS2 and the underlying implications in left ventricular noncompaction cardiomyopathy

A proteomics analysis seeking to identify proteins differentially accumulated in heart tissues of patients with Left Ventricular Noncompaction Cardiomyopathy (LVNC; 8 samples), Hypertrophic Cardiomyopathy (HCM; 7 samples), and Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC; 8 samples) (Figure 1A). Our comparative analysis of the four sample types identified which proteins were significantly up-regulated (fold change>1.2) and down-regulated (fold change<0.83) in LVNC, HCM, and ARVC hearts.