Synaptic and transcriptomic features of fear matrix pyramidal neurons predict inefficient fear extinction

Trauma-related disorders arise from inefficient fear extinction and have immeasurable social and economic costs. Here, we characterized mouse phenotypes that spontaneously show individual differences in adaptive or maladaptive fear extinction and, before the traumatic experience, we found that specific morphological, electrophysiological and transcriptomic patterns of fear matrix pyramidal neurons predispose to trauma-related disorders. Finally, by using an optogenetic approach we showed the possibility to rescue the inefficient fear extinction activating fear matrix infralimbic pyramidal neurons Overall design: RNA extracted from amygdala pyramidal neurons of 9 B6.Cg-Tg(Thy1-YFP)HJrs/J (Thy1-YFP; Jackson Laboratories, Maine, USA) transgenic mice