Population-based computational simulations elucidate mechanisms of focal arrhythmia following stem cell injection

This dataset contains the data required to reproduce the computational simulations presented in the 2025 paper by Gibbs and Boyle. This dataset comprises (1) Geometric descriptions of the simulation domain (whole heart, tissue wedge, etc.), with point clouds interconnected by finite elements, each of which is associated with a vector encoding the local myofiber orientation. (2) Parameter files describing functional cell- and tissue-scale properties of different tissue regions, perturbations to be applied to the model during the simulation (e.g., electrical stimuli), and numerical solver settings. (3) Initial condition state files describing the functional state of the model at the beginning of the simulation, if these conditions differ from the cell-scale default parameters. All of the above are stored in plain text or binary formats compatible with the openCARP framework, which is freely available for non-commercial use., , # Population-based computational simulations elucidate mechanisms of focal arrhythmia following stem cell injection

INFORMATION ABOUT THE RELATED PUBLICATION

Gibbs and Boyle(2025) Population-Based Computational Simulations Elucidate Mechanisms
of Focal Arrhythmia Following Stem Cell Injection (DOI: 10.1016/j.yjmcc.2025.04.010,
PMID: 40280466, link: [https://pubmed.ncbi.nlm.nih.gov/40280466/](https://pubmed.ncbi.nlm.nih.gov/40280466/))

Please contact Dr. Patrick M. Boyle ([[e-mail]](mailto:[e-mail])) with any questions, concerns,
complaints, or difficulties.

This dataset contains data required to reproduce computational simulations presented in the 2025 JMCC paper by Gibbs & Boyle.

#### Description of the data and file structure

Dryad_Figure3and7.xlsx provides the raw data Graphs of 3A and 7D-F. Raw values are given as percentage of simulations where GHE (graft-host excitation) was observed. Figure 3A summarizes the incidence of graft-host exchange (GHE) observed for ...,