Crystal structure of the Fab fragment of necitumumab (Fab11F8) in complex with domain III from a cetuximab resistant variant of EGFR (sEGFRd3-S468R)
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Crystal structure of the Fab fragment of necitumumab (Fab11F8) in complex with domain III from a cetuximab resistant variant of EGFR (sEGFRd3-S468R) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Epidermal growth factor receptor, ... Authors: Ferguson, K.M, Bagchi, A. Deposit date: 2017-09-23 Release date: 2017-12-06 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Molecular Basis for Necitumumab Inhibition of EGFR Variants Associated with Acquired Cetuximab Resistance. Mol. Cancer Ther., 17, 2018
奈昔木单抗（necitumumab）Fab片段（Fab11F8）与表皮生长因子受体（Epidermal Growth Factor Receptor, EGFR）西妥昔单抗耐药变体的结构域III（sEGFRd3-S468R）形成复合物的晶体结构。
描述项：2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖、2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1-4)-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖、表皮生长因子受体……
作者：Ferguson, K.M.、Bagchi, A.
入库日期：2017-09-23
发布日期：2017-12-06
最后修改日期：2024-10-16
实验方法：X射线衍射（2.8 Å）
引用文献：《奈昔木单抗抑制获得性西妥昔单抗耐药EGFR变体的分子机制》，Mol. Cancer Ther., 17, 2018
创建时间：
2017-09-23
