Structure of bovine endothelial nitric oxide synthase heme domain in complex with (S)-6-(2-amino-2-(3-(2-(4-methylpyridin-2-yl)ethyl)phenyl)ethyl)-4-methylpyridin-2-amine

Structure of bovine endothelial nitric oxide synthase heme domain in complex with (S)-6-(2-amino-2-(3-(2-(4-methylpyridin-2-yl)ethyl)phenyl)ethyl)-4-methylpyridin-2-amine Descriptor: (S)-6-(2-amino-2-(3-(2-(4-methylpyridin-2-yl)ethyl)phenyl)ethyl)-4-methylpyridin-2-amine, 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, ... Authors: Chreifi, G, Li, H, Poulos, T.L. Deposit date: 2014-03-15 Release date: 2014-05-07 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (2.01 Å) Cite: Nitric Oxide Synthase Inhibitors that Interact with Both a Heme Propionate and Tetrahydrobiopterin Show High Isoform Selectivity. J.Med.Chem., 57, 2014

牛内皮型一氧化氮合酶（bovine endothelial nitric oxide synthase）血红素结构域（heme domain）与(S)-6-(2-氨基-2-(3-(2-(4-甲基吡啶-2-基)乙基)苯基)乙基)-4-甲基吡啶-2-胺的复合物结构。描述：(S)-6-(2-氨基-2-(3-(2-(4-甲基吡啶-2-基)乙基)苯基)乙基)-4-甲基吡啶-2-胺、5,6,7,8-四氢生物蝶呤（5,6,7,8-TETRAHYDROBIOPTERIN）、乙酸根离子（ACETATE ION）…… 作者：Chreifi, G、Li, H、Poulos, T.L. 沉积日期：2014-03-15 发布日期：2014-05-07 最后修改日期：2024-11-13 实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.01埃（Å）。引用文献：《可同时结合血红素丙酸酯与四氢生物蝶呤的一氧化氮合酶抑制剂具有高亚型选择性》，《药物化学杂志》（J.Med.Chem.），第57卷，2014年