Innovative-Process-Applications/ipa-pharma-compactor-platform

--- license: cc-by-4.0 language: - en pretty_name: "IPA Pharmaceutical Roller Compactor Platform: Scale-Up & Performance (Synthetic)" size_categories: - 1K<n<10K task_categories: - tabular-regression tags: - roller-compaction - pharmaceutical-manufacturing - dry-granulation - scale-up - quality-by-design - twin-feed-screw - process-engineering - synthetic-data - education configs: - config_name: default data_files: - split: train path: "ipa_pharma_compactor_v1.0.csv" --- # IPA Pharmaceutical Roller Compactor Platform: Scale-Up & Performance (Synthetic) **Version:** 1.0 **Publisher:** [Innovative Process Applications (IPA)](https://www.innovativeprocess.com) **License:** Creative Commons Attribution 4.0 International (CC BY 4.0) > ⚠️ **This dataset is 100% synthetic and intended for educational use only.** > Generated from IPA's published CL-series specifications and standard > compaction physics — not real production or clinical batch data. --- ## What's in this dataset 3,000 simulated pharmaceutical roller compaction runs spanning IPA's complete CL-series platform — from R&D lab (CL25150, 5 HP) through full production (CL100250, 25 HP) — across 5 pharma/nutraceutical materials and the full operating envelope of twin-feed-screw process parameters. ### Equipment specifications (from IPA published data) | Model | Roll Size | Max Pressure | Integrated Mill | Power | Scale | |---|---|---|---|---|---| | CL25150 | 1"×6" (2.5×15 cm) | 17.5 kN/cm | None | 5 HP | R&D / Lab | | CL30200 | 1"×8" (3×20 cm) | 17.5 kN/cm | PM3 | 2.75 HP | Pilot | | CL50200 | 2"×8" (5×20 cm) | 26.0 kN/cm | PM6 | 12 HP | Pilot / Small Prod | | CL75200 | 3"×8" (7.5×20 cm) | 15.0 kN/cm | PM6 | 20 HP | Production | | CL100250 | 4"×10" (10×25 cm) | 17.5 kN/cm | PM8 | 25 HP | Full Production | ### Column descriptions | Column | Units | Description | |---|---|---| | `compactor_model` | — | IPA CL-series model | | `scale` | — | R&D / Lab, Pilot, Production, Full Production | | `roll_diameter_in` / `_cm` | in / cm | Roll diameter | | `roll_width_in` / `_cm` | in / cm | Roll width | | `max_roll_pressure_kn_cm` | kN/cm | Maximum specific compaction force | | `integrated_mill` | — | PM-series in-air impact mill (or None) | | `total_power_kw` | kW | Total system power | | `material` | — | Pharma material identifier | | `feed_density_gcc` | g/cc | Feed powder bulk density | | `deformation_type` | — | Plastic, brittle, or mixed | | `roll_pressure_fraction` | — | Fraction of max pressure applied (0.3–1.0) | | `scf_kn_cm` | kN/cm | Actual specific compaction force | | `roll_speed_rpm` | rpm | Roll rotation speed | | `hfs_speed_rpm` | rpm | Horizontal feed screw speed (controls throughput) | | `vfs_hfs_ratio` | — | Vertical/horizontal feed screw speed ratio (controls pre-compression) | | `gap_width_mm` | mm | Roll gap | | `ribbon_rel_density` | — | Relative density (fraction of true density) | | `ribbon_density_gcc` | g/cc | Absolute ribbon density | | `ribbon_porosity` | — | 1 − relative density | | `density_cv_pct` | % | Across-ribbon density uniformity | | `fines_pct` | % | Fines fraction after milling | | `granule_yield_pct` | % | Usable granule yield | | `in_zinchuk_window` | Yes/No | Ribbon RD in 0.60–0.80 tabletability range | | `throughput_kg_hr` / `_lbs_hr` | kg/hr / lbs/hr | Mass throughput | | `specific_energy_kwh_tonne` | kWh/tonne | Energy efficiency | | `changeover_time_hr` | hours | Estimated changeover time | ## IPA platform advantages demonstrated in the data 1. **Twin feed screw (HFS + VFS):** Independent control of throughput (HFS) and pre-compression (VFS) produces a uniquely tunable operating space. The VFS/HFS ratio is a key process parameter not available on single-screw compactors. 2. **Scalable platform:** Consistent ribbon quality (CV%, yield) across the CL25150 → CL100250 range, enabling direct R&D-to-production scale-up. 3. **Integrated in-air impact milling:** PM-series mills minimize heat generation and maximize granule yield with precise PSD control. 4. **Efficient changeover:** Modular design enables fast product changeover, critical for multi-product pharma facilities. 5. **Low bulk density capability:** Twin screw design is proven efficient with light powders (feed density 0.3–0.5 g/cc) containing high air content. ## Cross-links - **Kaggle:** [link after publication] - **Hugging Face:** [link after publication] - **Zenodo:** [link after publication] - **GitHub:** [link after publication] - **IPA website:** https://www.innovativeprocess.com ## Citation > Innovative Process Applications (2026). *IPA Pharmaceutical Roller Compactor > Platform: Scale-Up & Performance (Synthetic), v1.0*. CC BY 4.0. > https://www.innovativeprocess.com许可协议：CC BY 4.0 语言：英语 数据集名称："IPA制药辊压压实平台：放大与性能（合成数据集）" 样本规模：1000 < 样本数量 < 10000 任务类别：表格回归 标签： - 辊压压实（roller-compaction） - 制药生产（pharmaceutical-manufacturing） - 干式造粒（dry-granulation） - 工艺放大（scale-up） - 质量源于设计（quality-by-design） - 双进料螺杆（twin-feed-screw） - 过程工程（process-engineering） - 合成数据（synthetic-data） - 教育用途（education） 配置项： - 配置名称：default 数据文件： - 拆分集：训练集 路径：ipa_pharma_compactor_v1.0.csv # IPA制药辊压压实平台：放大与性能（合成数据集） **版本：1.0** **发布方：[创新工艺应用公司（Innovative Process Applications, IPA）](https://www.innovativeprocess.com)** **许可协议：知识共享署名4.0国际许可（CC BY 4.0）** > ⚠️ **本数据集为100%合成数据，仅用于教育目的。** > 数据基于IPA公开的CL系列设备规格与标准压实物理原理生成，而非实际生产或临床批次数据。 --- ## 数据集内容概览 本数据集包含3000次模拟制药辊压压实运行试验数据，覆盖IPA完整CL系列设备平台——从研发实验室级（CL25150，5 HP）到全生产级（CL100250，25 HP），涵盖5种制药/营养补充剂原料，以及双进料螺杆工艺参数的全操作范围。 ### 设备规格（源自IPA公开数据） | 型号 | 辊筒尺寸 | 最大比压力 | 集成式粉碎机 | 额定功率 | 应用层级 | |---|---|---|---|---|---| | CL25150 | 1"×6"（2.5×15 cm） | 17.5 kN/cm | 无 | 5 HP | 研发/实验室级 | | CL30200 | 1"×8"（3×20 cm） | 17.5 kN/cm | PM3 | 2.75 HP | 中试级 | | CL50200 | 2"×8"（5×20 cm） | 26.0 kN/cm | PM6 | 12 HP | 中试/小生产级 | | CL75200 | 3"×8"（7.5×20 cm） | 15.0 kN/cm | PM6 | 20 HP | 生产级 | | CL100250 | 4"×10"（10×25 cm） | 17.5 kN/cm | PM8 | 25 HP | 全生产级 | ### 字段说明 | 字段名 | 单位 | 说明 | |---|---|---| | `compactor_model` | — | IPA CL系列设备型号 | | `scale` | — | 应用层级，可选研发/实验室级、中试级、生产级、全生产级 | | `roll_diameter_in` / `_cm` | 英寸/厘米 | 辊筒直径 | | `roll_width_in` / `_cm` | 英寸/厘米 | 辊筒宽度 | | `max_roll_pressure_kn_cm` | kN/cm | 最大比压实力 | | `integrated_mill` | — | PM系列气流冲击粉碎机（或无） | | `total_power_kw` | kW | 系统总功率 | | `material` | — | 制药原料标识符 | | `feed_density_gcc` | g/cc | 进料粉末松散密度 | | `deformation_type` | — | 变形类型，可选塑性、脆性或混合型 | | `roll_pressure_fraction` | — | 实际辊压压力占最大压力的比例（0.3–1.0） | | `scf_kn_cm` | kN/cm | 实际比压实力 | | `roll_speed_rpm` | rpm | 辊筒转速（转每分钟） | | `hfs_speed_rpm` | rpm | 水平进料螺杆转速（转每分钟，控制产能） | | `vfs_hfs_ratio` | — | 垂直/水平进料螺杆转速比（控制预压缩程度） | | `gap_width_mm` | mm | 辊缝宽度 | | `ribbon_rel_density` | — | 带材相对密度（真实密度的占比） | | `ribbon_density_gcc` | g/cc | 带材绝对密度 | | `ribbon_porosity` | — | 1 − 相对密度，即带材孔隙率 | | `density_cv_pct` | % | 带材密度均匀性（变异系数百分比） | | `fines_pct` | % | 粉碎后细粉占比 | | `granule_yield_pct` | % | 可用颗粒收率 | | `in_zinchuk_window` | 是/否 | 带材相对密度处于0.60–0.80可压片范围 | | `throughput_kg_hr` / `_lbs_hr` | kg/hr / lbs/hr | 质量产能 | | `specific_energy_kwh_tonne` | kWh/吨 | 单位能耗（能源效率） | | `changeover_time_hr` | 小时 | 预估设备切换时间 | ## 本数据集体现的IPA平台优势 1. **双进料螺杆（HFS + VFS）**：通过独立控制产能（HFS）与预压缩（VFS），可实现操作区间的精准可调，打造独有的可调式运行空间。VFS与HFS的转速比是单螺杆压实机所不具备的关键工艺参数。 2. **可扩展平台**：CL25150至CL100250全系列设备的带材质量（变异系数、收率）保持一致，可实现从研发到生产的直接工艺放大。 3. **集成式气流冲击粉碎**：PM系列粉碎机可最大限度降低热生成，通过精准的粒度分布（PSD）控制实现颗粒收率最大化。 4. **高效换型**：模块化设计支持快速产品换型，对多产品制药工厂而言至关重要。 5. **低松散密度物料适配性**：双螺杆设计对含高空气量的轻质粉末（进料密度0.3–0.5 g/cc）表现出优异的处理效率。 ## 关联链接 - **Kaggle：** [发布后公布链接] - **Hugging Face：** [发布后公布链接] - **Zenodo：** [发布后公布链接] - **GitHub：** [发布后公布链接] - **IPA官方网站：** https://www.innovativeprocess.com ## 引用 > 创新工艺应用公司（Innovative Process Applications, IPA）(2026). *IPA制药辊压压实平台：放大与性能（合成数据集），v1.0*. CC BY 4.0. https://www.innovativeprocess.com