Candidate Genes for Experimental Validation.

Notes: We ranked genes not included in our mESC gold standard by network topology measures: self-renewal correlation (SRC) and scaled network degree (K). We used network degree to identify hubs and topologically important gene nodes, and SRC scores to discover genes functionally related to mESC self-renewal. Our highest confidence potentially novel self-renewal genes (in bold) ranked high in both gene lists and were not yet annotated to biological processes associated with self-renewal or cell fate determination.