Rational Design of High Affinity Peptides Validates Histone Chaperone ASF1 as a New Epigenetic Target in Cancer
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https://www.omicsdi.org/dataset/pride/PXD013279
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资源简介：
Starting from the structure of the human ASF1-histone complex, we developed a rational design strategy combining epitope tethering and optimization of interface contacts to identify a potent peptide inhibitor with a dissociation constant of 3 nM. LC-MS/MS was used to identify in vivo targets of the most prominent peptide inhibitor.
创建时间：
2019-09-25
