Parameter estimates explaining the kinetics of Th1 and Th2 responses in sheep experimentally infected with MAP.

The basic model (Eqns. (1)–(6)) was fitted to the normalised IFN- (Th1 response) and antibody titers (Th2 response) data [20]. Dash “-” indicates that this parameter was fixed to its default value given in Table 1. Parameters , , , were constrained between and , while and were constrained between and . Estimated and values for the delayed switch and combined Th1/Th2 response data are a bit higher though reasonably comparable to the magnitude of naïve CD8+ T cell expansion estimated in studies [70], [71] to be in the order of and in mouse spleen. RSS stands for the residual sum of squares.