Post-assembly Modification of Phosphine Cages Controls Host–Guest Behavior

We report the design, synthesis, and post-assembly modification of a new phosphine-paneled supra­molecular cage framework, the anion binding ability of which can be modified rationally through selective post-assembly functionalization. The parent phosphine-paneled cage can be modified in situ through oxidation, methylation, or auration. These covalent and coordinative modifications to the exterior of the cage strongly influence the guest-binding properties of the host.