Clinical characteristics and histopathological changes of morphea; A single-center, retrospective study of 137 patients

Supplemental figure 1. Clinical variants of morphea: (A) plaque type on the upper back (B) linear (en coup de sabre) type (C) linear type with blaschkoid distribution (D) deep type accompanied with muscle atrophy (E) generalized type which showed isomorphic plaques covering the entire trunk. Supplemental figure 2. The three patterns of sclerosis in morphea: (A) Top-heavy pattern; moderate to severe sclerosis in the papillary to the superficial reticular dermis, while below the mid dermis is relatively spared. (B) Bottom-heavy pattern; moderate to severe sclerosis below the mid dermis, while papillary to the superficial reticular dermis is relatively spared. (C) Full-thickness pattern; moderate to severe sclerosis throughout the whole dermis. (Hematoxylin-eosin stain: x40.) Supplemental figure 3. Histopathological features associated with poor treatment response: (A) Severe degree of sclerosis, which showed extensive fibrosis into the deep dermis and subcutis. (B) Dense inflammatory infiltrates at the dermal-subcutaneous junction and adjacent fat tissue. (C) Presence of tissue eosinophils. (D) Prominent basal layer hyperpigmentation. (Hematoxylin-eosin stain: A, B and D x100; C x200.) Supplement Table I. Definition and criteria for the extent of histologic sclerosis (global sclerosis score) and the pattern of sclerosis. (Modified from Walker D et al, JAAD 2017;76:1124-30., and Verrecchia F et al, Rheumatology (Oxford, England) 2007;46:833-41.)