Neurogenetic Investigations of Obsessive-Compulsive Disorder

Obsessive-compulsive disorder (OCD) is a disabling early-onset neuropsychiatric disorder with a clear genetic contribution to risk but unclear underlying pathophysiology, which has hindered the development of new treatments and interventions. This study uses high-throughput sequencing approaches to identify OCD risk genes, detect gene expression differences in OCD, and determine epigenetic signatures driving gene expression in OCD brain. These studies will improve our understanding of the underlying mechanisms of OCD and identify points of traction for mechanistic studies in model systems, ultimately leading to novel therapeutics, and reducing the significant morbidity and mortality associated with this disabling illness. Furthermore, insights gained in these studies can inform gene discovery approaches to other complex neuropsychiatric disorders.]]>
Participants are probands meeting diagnostic criteria for obsessive-compulsive and related disorders, as defined by the Diagnostic and Statistical Manual for Mental Disorders (DSM-IV-TR or DSM-5), and both biological parents. Other diagnostic criteria include no previously diagnosed neurological disorder, intellectual disability, psychotic disorder, or OCD occurring exclusively in the context of depression. Final diagnostic status is assigned based on the consensus of an experienced interviewer and a psychiatrist or psychologist after independent review and administration of a structured diagnostic interview.]]>