<b>Nonlinear and Sex-Specific Associations of Vitamin D Metabolites with Inflammatory Blood Markers in 455,000 Adults</b>Item

Neutrophils and Monocytes: Displayed U-shaped associations with both 25(OH)D and 1,25(OH)₂D. Neutrophil counts were lowest at 25(OH)D levels of ~40–60 nmol/L and increased significantly at both lower and higher extremes (p &lt; 0.001). Lymphocytes: Inverse relationship with 25(OH)D (p &lt; 0.001), and an inverse U-shaped relationship with 1,25(OH)₂D, peaking at ~90 pmol/L, with counts decreasing at both lower and higher levels (p &lt; 0.001). Sex-specific analysis revealed that the relationship between 1,25(OH)₂D and lymphocyte count remained independent only in men, Eosinophils and Basophils: Demonstrated consistently negative correlations with both forms of vitamin D across all concentration ranges (p &lt; 0.001).