Changes in insulin secretion and IS due to overfeeding (OF) caloric restriction (CR) and refeeding (RF) (values are means ±SD).

†p<0.05 ††p<0.01 †††p<0.001 significantly different from baseline *p<0.05 **p<0.01 ***p<0.001 significantly different from previous period; Repeated measures ANOVA with Bonferroni adjustments IS, insulin sensitivity; HOMA-index, homeostasis model assessment of insulin resistance; OGTT, oral glucose tolerance test; iAUC, incremental area under the curve; tAUC, total area under the curve; Matsuda-ISI, Mastsuda insulin sensitivity index Changes in insulin secretion and IS due to overfeeding (OF) caloric restriction (CR) and refeeding (RF) (values are means ±SD).