Overview over main resources used in this work.

The phenotype data resulting from single gene mutations and genetic interaction data for Drosophilae, Mus musculus, Saccharomyces cerevisiae, Caenorhabditis elegans and Danio rerio were downloaded from FlyBase[10], Mouse Genome Informatics[13], Saccharomyces Genome Database [9], WormBase[12], and Zebrafish Information Network (ZFIN) database [11] respectively. All phenotype data was downloaded on 11 Nov 2012. GO annotations were downloaded from the GOA website on 13 Nov 2012. The ontologies as well as the phenotype definitions were obtained from the OBO Foundry website on 13 Nov 2012. For zebrafish, we downloaded the files Morpholinos.txt and genotype_features.txt on 02 Oct 2012 from the ZFIN website. We use these files to map ZFIN genotype and Morpholino identifiers to ZFIN’s gene identifiers.