Neurometabolic profile of the amygdala in smokers assessed with 1H-magnetic resonance spectroscopy - Data

1H-magnetic resonance spectroscopy (MRS) data and participant information for the article with the title: Neurometabolic profile of the amygdala in smokers assessed with 1H-magnetic resonance spectroscopy. The aims of the study were to compare glutamate and other metabolites in the amygdala (an area implied to play an important role in nicotine addiction) between smokers and controls, and between different smoking states. Furthermore, associations between amygdalar metabolite levels and smoking characteristics were explored. The data set comprises 28 male smokers and 21 non-smoking, matched controls. Controls were measured once (baseline) and smokers were measured in a baseline state (1-3 hours abstinence), during withdrawal (24 hours abstinence) and in a satiation state (directly after smoking). Voxel composition, spectral quality, and for the metabolites of interest, Cramér-Rao lower bounds and molar concentrations were measured using a novel non-water-suppressed 1H-MRS protocol. Good spectral quality, high anatomical specificity and reliable quantification of most metabolites of interest were achieved, providing first insights into the neurometabolic profile of the amygdala in smokers. Metabolite levels did not differ between groups, but smokers showed significantly lower glutamine levels at satiation than baseline. Details of the procedure and analysis are provided in the article (https://doi.org/10.1016/j.neuroimage.2024.120525).