Structure of Nicotinamide N-Methyltransferase (NNMT) in complex with II399 (P1 space group)
收藏Protein Data Bank Japan2023-10-18 更新2026-04-19 收录
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Structure of Nicotinamide N-Methyltransferase (NNMT) in complex with II399 (P1 space group) Descriptor: 3-[3-(acetyl{[(1R,2R,3S,4R)-4-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-2,3-dihydroxycyclopentyl]methyl}amino)prop-1-yn-1-yl]benzamide, NNMT protein, SULFATE ION Authors: Yadav, R, Noinaj, N, Iyamu, I.D, Huang, R. Deposit date: 2021-07-22 Release date: 2022-07-20 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.08 Å) Cite: Exploring Unconventional SAM Analogues To Build Cell-Potent Bisubstrate Inhibitors for Nicotinamide N-Methyltransferase. Angew.Chem.Int.Ed.Engl., 61, 2022
烟酰胺N-甲基转移酶（Nicotinamide N-Methyltransferase, NNMT）与II399复合物的晶体结构（空间群P1）。配体为3-[3-(乙酰基{[(1R,2R,3S,4R)-4-(4-氯-7H-吡咯并[2,3-d]嘧啶-7-基)-2,3-二羟基环戊基]甲基}氨基)丙-1-炔-1-基]苯甲酰胺，体系包含NNMT蛋白与硫酸根离子。作者：Yadav R、Noinaj N、Iyamu I.D、Huang R。提交日期：2021-07-22，发布日期：2022-07-20，最后更新日期：2023-10-18。实验方法：X射线衍射（分辨率2.08 Å）。引用文献：《探索非常规S-腺苷甲硫氨酸（S-adenosylmethionine, SAM）类似物以构建具有细胞活性的烟酰胺N-甲基转移酶双底物抑制剂》，Angew.Chem.Int.Ed.Engl., 61, 2022
创建时间：
2021-07-22
