Experiments to test AAV rescue of inducible arginase-1 deficient mice.

Notes:
*Age of mice is based on the day of the first tamoxifen administration.
Timing of viral administration is relative to the last dose of tamoxifen (designated 0) and is given in days (-14 refers to two weeks prior to the last dose of tamoxifen, while +7 refers to one week after the last dose. Several extra vehicle-injected control mice were included in the studies (not shown in Table) to exclude viral-mediated toxicity.
#Mouse A2 was euthanized at Day +21, even though healthy (within 2% of starting body weight and expressing 75% of control liver arginase activity; see Fig 8D.
!Mouse died due to non-viral mediated testicular morbidity.
CB7, hybrid cytomegalovirus enhancer/chicken β-actin promoter; TBG, thyroxine-binding globulin promoter. Mouse designation corresponds with data found in Fig 8C and 8D.
♂, male;
♀, female.
Experiments to test AAV rescue of inducible arginase-1 deficient mice.