Ins2

This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. The encoded precursor protein undergoes proteolytic cleavage to produce a disulfide-linked heterodimeric functional protein that is stored in secretory granules. An increase in blood glucose levels, among others, induces the release of insulin from the secretory granules. Mice deficient in the functional hormone encoded by this gene develop diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

本基因编码胰岛素，一种在碳水化合物和脂质代谢调节中发挥关键作用的肽类激素。编码的前体蛋白经过蛋白酶水解裂解，产生由二硫键连接的异源二聚体功能性蛋白，该蛋白储存于分泌颗粒中。血液葡萄糖水平的升高，以及其他因素，会诱导胰岛素从分泌颗粒中释放。缺乏由本基因编码的功能性激素的鼠类会发展成糖尿病。选择性剪接导致多种转录变体。[由 RefSeq 提供，2015 年 8 月]