Phase II study of dose-escalation of Regorafenib for patients with previously treated metastatic colorectal cancer.
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Interventions: Regorafenib is administered orally once daily for 21 days followed by 7 days rest. The initial dose of regorafenib is 80mg/day, and dose-escalation to 120mg or 160mg/day should be considered every two weeks. Primary outcome(s): Time to Treatment Failure Study Design: Single arm Non-randomized
创建时间:
2014-07-15



