PLA2G2A

The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5' UTRs have been found for this gene.[provided by RefSeq, Sep 2009]

该基因编码的蛋白质属于磷脂酶A2家族（PLA2）。PLA2s在序列、功能、定位以及二价阳离子需求方面构成一个多样化的酶家族。本基因产物属于II组，该组包含分泌型PLA2，一种分子质量较低、催化过程中需要钙离子的细胞外酶。该酶催化磷脂酰甘油中sn-2脂肪酸酰基酯键的水解，释放游离脂肪酸和溶血磷脂，并被认为是参与生物膜中磷脂代谢调节的活性物质。针对该基因，已发现存在几种具有不同5'非编码区（UTR）的剪接转录变体。[由RefSeq提供，2009年9月]