Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one

Cholest-5-ene-3beta,7alpha,24(S)-triol and NAD+ react to form 4-cholesten-7alpha,24(S)-diol-3-one and NADH + H+, catalyzed by HSD3B7 (3 beta-hydroxysteroid dehydrogenase type 7) in the endoplasmic reticulum membrane. Its function in vivo has been confirmed in studies of patients with defects in bile acid synthesis (Schwarz et al. 2000).

胆固醇-5-烯-3β,7α,24(S)-三醇与NAD+反应生成4-胆固醇-7α,24(S)-二醇-3-酮和NADH + H+，此反应由内质网膜上的HSD3B7（3β-羟基类固醇脱氢酶7型）催化。其在体内的功能已在研究胆汁酸合成缺陷患者的实验中得到证实（Schwarz等，2000年）。