Transcriptome analysis of Methylomonas sp. DH-1 wild-type and ?watR strain according to acetate treatment

WatR (weak acid tolerance regulator) was discovered to contribute to the tolerance against several organic acids. Generally, deletion of watR gene caused decreased tolerance. However, in the case of acetate, the tolerance has been increased according to the absence of watR. In order to determine the relationship between WatR and acetate, we tried to discover the acetate responsive genes in wild-type and ?watR strain. Overall design: To discover the target genes which are directly regulated by WatR upon acetate stress, the gene expression of wild-type was analyzed before/after acetate treatment and compared to the result of ?watR strain.