The quality changes in fresh frozen plasma of the blood donors at high altitude

ObjectiveAccording to the international guidelines, fresh frozen plasma (FFP) is unanimously used to treat coagulation disorders. The quality of FFP is critical for the clinical transfusion. Till now, few studies have integratedly evaluated the differences of FFP from blood donors at between high altitude (HA) and low altitude (LA). Besides, there were no special quality standards for HA FFP in China.Materials and methodsUp to 41 HA (Lhasa, 3700 m) and 46 LA (Chengdu, 500 m) blood donors were included in our study to estimate the differences of FFP from HA and LA blood donors. The concentration of total plasma proteins, prothrombin time (PT), activated partial thromboplastin time (aPTT), thrombin time (TT), fibrinogen (Fbg), factor (F) II, FV, FVII, FVIII, FIX, FX, FXI, FXII, D-dimer, protein C (PC), protein S (PS), antithrombin III (ATIII) and von Willebrand factor antigen (vWF:Ag) were determined, respectively.ResultsAs compared with FFP of LA blood donors, the total protein content of HA blood donors showed a significant decrease (65.2±8.9 vs.57.2±6.3 g/L; p

根据国际指南，新鲜冰冻血浆（FFP）被一致用于治疗凝血障碍。FFP的质量对于临床输血至关重要。迄今为止，仅有少数研究综合评估了来自高海拔（HA）和低海拔（LA）献血者FFP的差异。此外，中国尚未制定针对高海拔FFP的特殊质量标准。材料与方法：本研究纳入了41名高海拔（拉萨，海拔3700米）和46名低海拔（成都，海拔500米）献血者，以评估HA和LA献血者FFP的差异。分别测定了总血浆蛋白浓度、凝血酶原时间（PT）、活化部分凝血活酶时间（aPTT）、凝血酶时间（TT）、纤维蛋白原（Fbg）、因子（F）II、FV、FVII、FVIII、FIX、FX、FXI、FXII、D-二聚体、蛋白C（PC）、蛋白S（PS）、抗凝血酶III（ATIII）和冯·威勒布兰德因子抗原（vWF:Ag）。结果：与LA献血者的FFP相比，HA献血者的总蛋白含量显著降低（65.2±8.9 vs. 57.2±6.3 g/L；p