Crystal Structure of WT HIV-1 Protease (NL4-3) with Inhibitor NR03-92

Crystal Structure of WT HIV-1 Protease (NL4-3) with Inhibitor NR03-92 Descriptor: (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(2S,3R)-3-hydroxy-4-{[(1R)-1-hydroxy-2,3-dihydro-1H-indene-5-sulfonyl](2-methylpropyl)amino}-1-phenylbutan-2-yl]carbamate, Protease, SULFATE ION Authors: Shaqra, A.M, Kaur, J, Schiffer, C.A. Deposit date: 2025-08-19 Release date: 2025-12-24 Last modified: 2026-01-07 Method: X-RAY DIFFRACTION (1.87 Å) Cite: Fluorinated HIV-1 protease inhibitors containing chiral hydroxyethylbenzene and indanol as P2' ligands with potent activity against drug-resistant variants. Eur.J.Med.Chem., 304, 2025