Transcription–replication conflicts underlie sensitivity to PARP inhibitors
收藏NIAID Data Ecosystem2026-05-10 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE220223
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To examine replication fork progression firing upon TIMELESS/TIPIN knockdown, EdUseq was performed in HeLa cells transfected with siCTRL, siTIMELESS or siTIPIN, synchronised with Thymidine and then released for 120 min in S phase, with the last 30 minutes being labeled with EdU. Cells were collected by mitotic shake-off and allowed to progress through the cell cycle for 12 hours in the presence of 5-ethynyl2′-deoxyuridine (EdU) and hydroxyurea (HU). EdU-labelled DNA was then isolated and subjected to high-throughput sequencing (EdUseq-HU)
创建时间：
2025-09-16
