Crystal structure of an activated (Thr->Asp) Polo-like kinase 1 (Plk1) catalytic domain in complex with Compound 562

Crystal structure of an activated (Thr->Asp) Polo-like kinase 1 (Plk1) catalytic domain in complex with Compound 562 Descriptor: 4-({1-[3-(3-amino-3-oxopropyl)-5-chlorophenyl]-3-methyl-1H-pyrazolo[4,3-c]pyridin-6-yl}amino)-3-methoxy-N-(1-methylpipe ridin-4-yl)benzamide, Polo-like kinase Authors: Elling, R.A, Zhu, J, Barr, K.J, Romanowski, M.J. Deposit date: 2008-05-31 Release date: 2008-10-07 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors. Bioorg.Med.Chem.Lett., 18, 2008

本数据集为激活型（苏氨酸突变为天冬氨酸）polo样激酶1（Polo-like kinase 1, Plk1）催化结构域与化合物562结合的晶体结构。化合物562的结构式描述为：4-({1-[3-(3-氨基-3-氧代丙基)-5-氯苯基]-3-甲基-1H-吡唑并[4,3-c]吡啶-6-基}氨基)-3-甲氧基-N-(1-甲基哌啶-4-基)苯甲酰胺。本数据集相关作者为Elling, R.A.、Zhu, J、Barr, K.J.、Romanowski, M.J.。数据存放日期为2008-05-31，发布日期为2008-10-07，最后修改日期为2023-08-30。结构解析方法为X射线衍射（分辨率3.2 Å）。引用文献：《2-氨基吡唑并吡啶类化合物作为polo样激酶1抑制剂的设计与合成》，《生物有机与药物化学快报》，18卷，2008年。