Major histocompatibility complex genes have an increased brain expression after scrapie infection.
收藏PubMed Central1993-01-01 更新2026-05-16 收录
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https://pmc.ncbi.nlm.nih.gov/articles/PMC45610/
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资源简介：
We have examined the expression of the major histocompatibility complex (MHC) antigens and related genes in scrapie-infected hamster brain. Both the class I and the class II MHC genes as well as the class II-associated invariant chain were found to have an increased brain expression after scrapie infection. The increased expression of the class I complex was immunohistochemically localized primarily to neurons, though some astrocytes contained much smaller amounts of the class I complex. While there is no detectable immune response to scrapie infection, the possibility that increased MHC expression affords some defense against the scrapie agent is discussed. IMAGES:
提供机构：
National Academy of Sciences
创建时间：
1993-01-01
