Description of seizures following vaccinations in children with SCN1A-related Dravet syndrome.

Children 1–2 had been diagnosed at stage 1 and children 3–11 at stage 2 of the study by their treating physician. Children 12–15 were diagnosed at stage 2, by means of this study.DTwP-IPV-Hib = Diphtheria, Tetanus, whole-cell Pertussis, inactivated Polio vaccine, Haemophilus influenzae type b; FS = febrile seizure; GTCS = Generalized tonic clonic seizure; ND = not determined; h = hours. NA = not available.*Use of valium rectiole or intravenous;**DNA diagnostics performed by DNA Diagnostic Unit of the Neurogenetics Group, VIB Department of Molecular Genetics, University of Antwerp; unaffected parent mosaic for mutation.***Seizure was reported to the RIVM, but was not recognized as a seizure by either parents or co-workers of the RIVM.