Table_3_Dietary copper intake and risk of myocardial infarction in US adults: A propensity score-matched analysis.DOC

ObjectivesMost studies have examined the association between serum copper and myocardial infarction, but there is little evidence of the association between dietary copper intake and myocardial infarction.Materials and methodsThe study included a total of 14,876 participants from the 2011 to 2018 National Health and Nutrition Examination Survey (NHANES). Multivariate logistic regression model was used to analyze the association between dietary copper intake and the risk of myocardial infarction. To reduce selection bias, we use nearest neighbor propensity score matching (PSM) in a 1:2 ratio. Restricted cubic spline (RCS) method is used to study the non-linear relationship. Subgroup stratification was used to further investigate the association between copper intake and myocardial infarction.ResultsThe median dietary copper intake was 1.0825 mg/day. A myocardial infarction had occurred in approximately 4.4% (655) of the participants. Before and after matching, multivariate logistic regression models revealed a negative correlation between dietary copper intake and the risk of myocardial infarction. The higher quartile of subjects had a noticeably lower risk of myocardial infarction in comparison to those in the first quartile of copper intake. According to RCS findings, dietary copper intake and myocardial infarction have a non-linear and dose-response relationship. According to stratified analysis, the dietary copper intake was a substantial protective element for those who were ≥ 50 years old, female, 25 ≤BMI

研究目标：诸多研究业已探讨血清铜与心肌梗死之间的关联，然而，关于膳食铜摄入与心肌梗死之间关系的证据则相对匮乏。研究方法：本研究纳入了2011年至2018年国家健康与营养调查（NHANES）中的14,876名参与者。采用多因素逻辑回归模型分析膳食铜摄入与心肌梗死风险之间的关联。为降低选择偏差，我们采用1:2比例的邻近邻域倾向得分匹配（PSM）方法。通过限制性三次样条（RCS）法探究非线性关系。此外，运用亚组分层进一步研究铜摄入与心肌梗死之间的关联。研究结果：膳食铜摄入的中位数为1.0825毫克/日。约4.4%（655名）的参与者发生了心肌梗死。在匹配前后，多因素逻辑回归模型均显示膳食铜摄入与心肌梗死风险之间存在负相关性。与铜摄入第一四分位数相比，高四分位数组的参与者心肌梗死风险显著降低。根据RCS分析结果，膳食铜摄入与心肌梗死之间存在非线性且剂量反应的关系。根据分层分析，对于年龄≥50岁、女性、BMI在25至≤30范围内的个体，膳食铜摄入是一个重要的保护因素。