Stereopure phosphoryl guanidine backbone chemistry increases the potency and durability of gene silencing by RNA interference. Stereopure phosphoryl guanidine backbone chemistry increases the potency and durability of gene silencing by RNA interference

To investigate the potential of "off target" of RNAi knockdown, primary mouse hepatocytes were treated with molecules targeting Ttr. We then performed gene expression profiling analysis using data obtained from RNA-seq of cell at two different doses along with an untreated control. Overall design: Comparative gene expression profiling analysis of RNA-seq data for primary mouse hepatocytes cells of RNAi targeting Ttr.