Synergistic effects of Erlotinib and MET inhibitors in ERL-resistant NSCLC cell lines.

Dose-effect curves were calculated using CompuSyn plotting the entered Fa values against the entered dose values. For combination treatments, the combined drugs dose were entered. Each data point represents the mean of 3 replicates. Combination index (CI) values were generated by non-linear regression method. Trendlines indicate CI values at any given effect (Fa, fraction affected, %inhibition), actual data points are also shown. CI = 1, additivity; CI >1, antagonism; CI<1, synergy.