Crystal structure of malate dehydrogenase from Plasmodium Falciparum in complex with 4-(3,4-difluorophenyl)thiazol-2-amine

Crystal structure of malate dehydrogenase from Plasmodium Falciparum in complex with 4-(3,4-difluorophenyl)thiazol-2-amine Descriptor: 4-[3,4-bis(fluoranyl)phenyl]-1,3-thiazol-2-amine, Malate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... Authors: Romero, A.R, Calderone, V, Gentili, M, Lunev, S, Groves, M, Popowicz, G, Domling, A, Sattler, M. Deposit date: 2019-04-01 Release date: 2020-04-15 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2 Å) Cite: A Fragment-Based Approach Identifies an Allosteric Pocket that Impacts Malate Dehydrogenase Activity Commun Biol, 2021

恶性疟原虫（Plasmodium Falciparum）苹果酸脱氢酶（Malate dehydrogenase）与4-(3,4-二氟苯基)噻唑-2-胺形成复合物的晶体结构。配体描述信息：4-[3,4-二氟苯基]-1,3-噻唑-2-胺、苹果酸脱氢酶、烟酰胺腺嘌呤二核苷酸（NICOTINAMIDE-ADENINE-DINUCLEOTIDE）…… 作者：Romero, A.R、Calderone, V、Gentili, M、Lunev, S、Groves, M、Popowicz, G、Domling, A、Sattler, M。提交日期：2019-04-01；发布日期：2020-04-15；最后修改日期：2024-01-24。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2埃。引用文献：《基于片段筛选的方法鉴定影响苹果酸脱氢酶活性的变构口袋》，发表于*Commun Biol*，2021年。