Alpha7-nicotinic acetylcholine receptor time resolved bound to epibatidine and PNU-120596 asymmetric state 2

Alpha7-nicotinic acetylcholine receptor time resolved bound to epibatidine and PNU-120596 asymmetric state 2 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... Authors: Burke, S.M, Noviello, C.M, Hibbs, R.E. Deposit date: 2023-12-05 Release date: 2024-02-21 Last modified: 2025-05-14 Method: ELECTRON MICROSCOPY (3.31 Å) Cite: Structural mechanisms of alpha 7 nicotinic receptor allosteric modulation and activation. Cell, 187, 2024

Alpha7-烟碱型乙酰胆碱受体（Alpha7-nicotinic acetylcholine receptor）结合埃巴替丁（epibatidine）与PNU-120596的不对称状态2时间分辨结合结构。描述符：2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖（2-acetamido-2-deoxy-beta-D-glucopyranose）、2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1→4)-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖、钙离子（CALCIUM ION）等。作者：Burke, S.M.、Noviello, C.M.、Hibbs, R.E.。存放日期：2023-12-05；发布日期：2024-02-21；最后修改日期：2025-05-14。实验方法：电子显微镜（ELECTRON MICROSCOPY），分辨率3.31埃（Å）。引用文献：《α7烟碱型受体变构调节与激活的结构机制》（Structural mechanisms of alpha 7 nicotinic receptor allosteric modulation and activation），《细胞》（Cell），第187卷，2024年。