Crystal structure of the second bromodomain (BD2) of human BRD3 bound to Ro3280

Crystal structure of the second bromodomain (BD2) of human BRD3 bound to Ro3280 Descriptor: 4-[(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino]-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide, Bromodomain-containing protein 3 Authors: Karim, M.R, Bikowitz, M, Schonbrunn, E. Deposit date: 2020-12-25 Release date: 2021-11-17 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Differential BET Bromodomain Inhibition by Dihydropteridinone and Pyrimidodiazepinone Kinase Inhibitors. J.Med.Chem., 64, 2021

人类BRD3（含溴结构域蛋白3，Bromodomain-containing protein 3）的第二个溴结构域（bromodomain, BD2）与Ro3280结合的晶体结构，配体为4-[(9-环戊基-7,7-二氟-5-甲基-6-氧代-6,7,8,9-四氢-5H-嘧啶并[4,5-b][1,4]二氮杂卓-2-基)氨基]-3-甲氧基-N-(1-甲基哌啶-4-基)苯甲酰胺。作者：Karim, M.R、Bikowitz, M、Schonbrunn, E。提交日期：2020-12-25，发布日期：2021-11-17，末次修改日期：2023-10-18。实验方法：X射线衍射（分辨率1.5 Å）。引用文献：《二氢蝶啶酮与嘧啶并二氮杂卓酮类激酶抑制剂对BET溴结构域的差异化抑制》，《Journal of Medicinal Chemistry》，2021年，第64卷。